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First-in-human study of IM156, a novel potent biguanide oxidative phosphorylation (OXPHOS) inhibitor, in patients with advanced solid tumors. Invest New Drugs, 40(5), 1001-1010.
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First-in-Human Evaluation of the Safety, Tolerability, and Pharmacokinetics of SPR720, a Novel Oral Bacterial DNA Gyrase (GyrB) Inhibitor for Mycobacterial Infections. Antimicrob Agents Chemother, 65(11), e0120821.
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Protective Effects of Dietary Grape on UVB-Mediated Cutaneous Damages and Skin Tumorigenesis in SKH-1 Mice. Cancers (Basel), 12(7).
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Roflumilast Cream Improves Signs and Symptoms of Plaque Psoriasis: Results from a Phase 1/2a Randomized, Controlled Study. J Drugs Dermatol, 19(8), 734-740.
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Chemoprotective Effects of Dietary Grape Powder on UVB Radiation-Mediated Skin Carcinogenesis in SKH-1 Hairless Mice. J Invest Dermatol, 139(3), 552-561.
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Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: A case study using aromatic amine mutagenicity. Regul Toxicol Pharmacol, 77, 1-12.
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Constitutive androstane receptor-mediated changes in bile acid composition contributes to hepatoprotection from lithocholic acid-induced liver injury in mice. Drug Metab Dispos, 37(5), 1035-1045.
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Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds. J Pharmacol Toxicol Methods, 58(3), 206-214.
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Induction of multi-drug resistance associated protein 3 (Mrp3) correlates with altered bile acid disposition and hepatoprotection during cholestasis in C57BL/6 mice. Drug Metabolism Reviews. 37(2): Abstract #61, p. 45
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Role of tyrosine kinase in platelet-activating factor receptor responses.  Jof Lipid Mediators and Cell Signaling. 10(1-2):33-4
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Platelet Activating Factor Receptor Functions Via Phosphoinositide Turnover and Tyrosine Kinase. In Shivendra D. Shukla (Ed.), Platelet Activating Factor Receptor:  Signal Mechanisms and Molecular Biology (pp. 41-60). CRC Press, Inc.
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Principles and Procedures for Assessment of Acute Toxicity Incorporating In Silico Methods. Comput Toxicol, 24.
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In silico approaches in organ toxicity hazard assessment: Current status and future needs for predicting heart, kidney and lung toxicities. Comput Toxicol, 20.
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Skin sensitization in silico protocol. Regul Toxicol Pharmacol, 116, 104688.
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Whole Fruit Phytochemicals Combating Skin Damage and Carcinogenesis. Transl Oncol, 13(2), 146-156.
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Grape Chemopreventive Agents Against Angiogenesis and Metastasis. In John M. Pezzuto & Ole Vang (Eds.), Natural Products for Cancer Chemoprevention: Single Compounds and Combinations (pp. 375-400).
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Principles and procedures for handling out-of-domain and indeterminate results as part of ICH M7 recommended (Q)SAR analyses. Regul Toxicol Pharmacol, 102, 53-64.
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Effects and Mechanism of Nicotinamide Against UVA- and/or UVB-mediated DNA Damages in Normal Melanocytes. Photochem Photobiol, 95(1), 331-337.
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Principles and procedures for implementation of ICH M7 recommended (Q)SAR analyses. Regul Toxicol Pharmacol, 77, 13-24.
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Copper-zinc superoxide dismutase-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis induced with myelin oligodendrocyte glycoprotein 35-55. J Neuroimmunol, 256(1-2),
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Pharmacokinetic and pharmacodynamic evaluation of the suitability of using fluticasone and an acute rat lung inflammation model to differentiate lung versus systemic efficacy. J Pharm Sci, 98(11), 4354-4364.
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Fluticasone and budesonide nanosuspensions for pulmonary delivery: preparation, characterization, and pharmacokinetic studies. J Pharm Sci, 97(11), 4869-4878.
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Subchronic studies in Sprague-Dawley rats to investigate mechanisms of MTBE-induced Leydig cell cancer. Toxicol Sci, 72(1), 31-42.
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Ethanol and Cell Tyrosine Kinase. In Christer Alling, et al. (Eds.), Alcohol, Cell Membranes, and Signal Transduction in Brain (pp. 273-282). Springer US.
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Purification and properties of parathyroid hormone-related peptide isolated from milk. Endocrinology, 126(2), 1183-1190.
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Protective effects of dietary grape against atopic dermatitis-like skin lesions in NC/NgaTndCrlj mice. Front Immunol, 13, 1051472.
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In silico approaches in organ toxicity hazard assessment: current status and future needs in predicting liver toxicity. Comput Toxicol, 20.
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Quercetin-Resveratrol Combination for Prostate Cancer Management in TRAMP Mice. Cancers (Basel), 12(8).
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Clinical stage molecule PT150 is a modulator of glucocorticoid and androgen receptors with antiviral activity against SARS-CoV-2. Cell Cycle, 19(24), 3632-3638.
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Genetic toxicology in silico protocol. Regul Toxicol Pharmacol, 107, 104403.
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Identification of Molecular Targets of Dietary Grape-Mediated Chemoprevention of Ultraviolet B Skin Carcinogenesis: A Comparative Quantitative Proteomics Analysis. J Proteome Res, 18(10), 3741-3751.
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In silico toxicology protocols. Regul Toxicol Pharmacol, 96, 1-17.
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Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice. Toxicol Lett, 188(1), 38-44.
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Minimal role of hepatic transporters in the hepatoprotection against LCA-induced intrahepatic cholestasis. Toxicol Sci, 102(1), 196-204.
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Identification of interspecies difference in efflux transporters of hepatocytes from dog, rat, monkey and human. Eur J Pharm Sci, 35(1-2), 114-126.
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Lack of respiratory and contact sensitizing potential of the intranasal antiviral drug candidate rupintrivir (AG7088): a weight-of-the-evidence evaluation. J Immunotoxicol, 2(3), 123-139.
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Determination of testosterone and 6beta-hydroxytestosterone by gas chromatography-selected ion monitoring-mass spectrometry for the characterization of cytochrome p450 3A activity. J Chromatogr B Biomed Sci Appl, 734(1), 73-81.
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Ethanol modulates epidermal growth factor-stimulated tyrosine kinase and phosphorylation of PLC-gamma 1. Biochem Biophys Res Commun, 185(3), 1062-1068.
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Bovine parathyroid tissue: a model to compare the biosynthesis and secretion of parathyroid hormone and parathyroid hormone-related peptide. Surgery, 106(6), 1057-1062.
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